Taking inventory with shotgun EM

EHPnet: Taking Inventory of Toxics

Many cellular systems rely on the ability to interpret spatial heterogeneities in chemoattractant concentration to direct cell migration. The accuracy of this process is limited by stochastic fluctuations in the concentration of the external signal and in the internal signaling components. Here we use information theory to determine the optimal scheme to detect the location of an external chemo...

Vamsi Mootha: Taking an inventory of mitochondria

Mitochondria, the energy reactors of the cell, are estimated to contain approximately 1,500 proteins, but the mito-chondrial genome itself only encodes about 13 of them. The remaining proteins are immigrants that are encoded by the nuclear genome. Vamsi Mootha is using an integrative genomics approach to identify all of these proteins and their functions and to understand how their mutated vers...

Taking the inventory inside single cells.

developed to measure cell-to-cell differences have typically been based on microscopic imaging of fluorescent proteins 1 or RNA 2,3. These techniques make it possible to monitor RNA or protein fluctuations both in single cells over time and across the cell population , and they are even capable of visualizing single molecules in single cells 4,5. However, they can only be used to monitor a few ...

Initial Characterization of the Large Genome of the Salamander <em>Ambystoma mexicanum</em> Using Shotgun and Laser Capture Chromosome Sequencing

مثال‌هایی از الگوریتم EM

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